Katsuo Kurabayashi Department of Mechanical and Aerospace Engineering NYU Tandon School of Engineering USA

Microfluidic Manipulation of Biomolecules, Cells, and Biochemical Assay Reagents for High-Performance Immunosensors

Immunosensors are biosensing devices designed to detect and quantify specific target molecules through antibody-antigen interactions. These devices hold great promise as versatile tools extensively utilized in medical diagnostics, environmental monitoring, and food safety testing. However, despite their potential, many immunosensors still demonstrate limited performance when employed in critical care medicine. This is particularly critical as they are needed for diagnosing and monitoring life-threatening immune disorders and hyper-inflammatory reactions resulting from severe infections, trauma, surgery, and immunotherapy side effects. This talk discusses our ongoing research efforts to advance immunosensor technology for critical care of septic shock by manipulating biomolecular transport, sorting cells, and automating biochemical assay processes in a microfluidic environment.